The Computational Mechanics of Materials group of IMDEA Materials Institute, headed by Dr. Jérusalem, is working on a research new line in collaboration with Prof. Peña of the Computer Science Department of the UPM, within the framework of the Cajal Blue Brain project. This line consists in studying the mechanical behaviour of neuron under different loading conditions by means of a coupled simulation and experimental approach. Two projects are currently ongoing at IMDEA Materials within this research line: one dealing with the electromechanical coupling within the different structures of the neuronal cell; and one on the structural evolution (mainly protein related) during the growth and migration of a neuron. These projects, in collaboration with medical and biological communities, and in synergy with de Cajal Blue Brain project´s goals, aim at bringing new simulation tools to the study of brain disease either due to sudden changes in the mechanical properties of the neurons (e.g. TBI) or to slowly evolving dysfunctions (e.g. Alzheimer or Huntington diseases).
Partners: Collaboration between IMDEA Materials Institute and the Polytechnic University of Madrid (Computer Science Department of the UPM)
Funding Organisation: UPM and IMDEA Materials Institute
Industrial sector: Medical and Biomaterials
Project period: 2010 – 2013
Principal Investigator: Dr. Antoine Jerusalem